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If not caught in time, Lyme Disease Symptoms will transform into even more serious indicators such as: paralysis of the face muscles, numbness and also joint pain. The rash which is a natural in this is normally described as red-colored bumpy rash which has a tiny round pattern in the center. The rash simply appears in around 30% of cases. Just like tertiary neurosyphilis, neuro psychiatric symptoms can be mainly observed in later phase.